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Mechanism for formation of Hollow and Granular Silica Aerogel Microspheres from rice husk ash for drug delivery

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Title Mechanism for formation of Hollow and Granular Silica Aerogel Microspheres from rice husk ash for drug delivery
 
Creator RAJANNA, SK
VINJAMUR, M
MUKHOPADHYAY, M
 
Subject SPHERES
RELEASE
STORAGE
NANOPARTICLES
PROPERTY
SYSTEM
Aerogels
Sol-gel
Hollow microspheres
Rice husk ash
Biogenic silica
Drug delivery
 
Description The present work describes a method for preparation of Hollow Silica Aerogel Microspheres (HSAMs) and Granular Silica Aerogel Microparticles (GSAMs) for drug delivery, from rice husk ash (RHA), an inexpensive source of bio-compatible silica. This method involves a two-step sol-gel process for preparation of wet gel microspheres using an improved sol-gel/mineral-oil emulsion (containing dual surfactants), followed by solvent exchange and aging in aqueous ethanol, to replace water in the microspheres with ethanol. It is shown that the amount and concentration of the ammonium hydroxide (NH4OH) solution added during gelation process determine if hollow or granular wet gel particles form. A mechanism for the formation of HSAMs or GSAMs is proposed and validated by experiments. The wet gel particles are subsequently dried with supercritical carbon dioxide at 150 bar and 50 degrees C to obtain HSAMs or GSAMs. HSAMs afford high loading of drugs as illustrated by loading of 0.47 g ibuprofen per g of HSAM. Further, a fast release of ibuprofen from loaded HSAMs compared to pure crystalline ibuprofen and other loaded forms, indicates that HSAMs produced by the present method are good drug delivery vehicles. (C) 2015 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2016-01-14T14:31:48Z
2016-01-14T14:31:48Z
2015
 
Type Article
 
Identifier JOURNAL OF NON-CRYSTALLINE SOLIDS, 429,226-231
0022-3093
1873-4812
http://dx.doi.org/10.1016/j.jnoncrysol.2015.09.015
http://dspace.library.iitb.ac.in/jspui/handle/100/17733
 
Language en