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Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies

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Title Bio-relevant complexes of novel N2O2 type heterocyclic ligand: Synthesis, structural elucidation, biological evaluation and docking studies
 
Creator ARUN, T
PACKIANATHAN, S
MALARVIZHI, M
ANTONY, R
RAMAN, N
 
Subject SCHIFF-BASE COMPLEXES
VITRO DNA-BINDING
MOLECULAR DOCKING
METAL-COMPLEXES
CLEAVAGE
NI(II)
CU(II)
CO(II)
INTERCALATION
CYTOTOXICITY
N2O2-Schiff base
DNA binding
DNA cleavage
Anti-pathogenic activity
Molecular docking
 
Description Organic and inorganic entities [Cu(II), Co(II), Ni(II) and Zn(II)] have been bridged by N2O2 type heterocyclic imine (-C=N) ligand for the synthesis of novel organic-inorganic bridged complexes of the type [M(H2L)]. The synthesized complexes were characterized by spectral techniques such as FT-IR, UV-visible, H-1 NMR, C-13 NMR, EPR, ESI-Mass, elemental analysis, magnetic susceptibility and molar conductivity measurements. The metal complexes adopt square planar geometrical arrangement around the metal ions. DNA binding ability of these complexes has been explored by different techniques viz, electronic absorption, fluorescence, cyclic voltammetry, differential pulse voltammetry and viscosity measurements. These studies prove that CT DNA interaction of the complexes follows intercalation mode. The oxidative cleavage of the complexes with pUC19 DNA has been investigated by gel electrophoresis. Molecular docking calculations have been performed to understand the nature of binding of the complexes with DNA. Moreover, the anti-pathogenic actions of the complexes were tested in vitro against few bacteria and fungi by disk diffusion method. The data reveal that the complexes have higher anti-pathogenic activity than the ligand. (C) 2015 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE SA
 
Date 2016-01-15T04:22:57Z
2016-01-15T04:22:57Z
2015
 
Type Article
 
Identifier JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 149,93-102
1011-1344
http://dx.doi.org/10.1016/j.jphotobiol.2015.05.022
http://dspace.library.iitb.ac.in/jspui/handle/100/17747
 
Language en