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Metabolomics and its integration with systems biology: PSI 2014 conference panel discussion report

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Title Metabolomics and its integration with systems biology: PSI 2014 conference panel discussion report
 
Creator MORE, T
ROYCHOUDHURY, S
GOLLAPALLI, K
PATEL, SK
GOWDA, H
CHAUDHURY, K
RAPOLE, S
 
Subject CLINICAL METABOLOMICS
STRATEGIES
BIOINFORMATICS
PERSPECTIVES
DATABASE
METACYC
KEGG
Metabolomics
Integrative approach
Biomarkers
Mass spectrometry
NMR
 
Description Metabolomics, being a relatively new field, is facing multiple challenges related to data acquisition and interpretation, reproducibility across analytical platforms, integration with other omics approaches and translation into theragnostic biomarkers. There is an immediate need to overcome these challenges in order to make metabolomics more useful and reliable in terms of improving our current understanding of disease biology and help in developing predictive biomarkers. Researchers interested in metabolomics gathered for a panel discussion on 'Metabolomics and its integration with systems biology' during the 6th Annual Meeting of Proteomics Society-India and International Conference on "Proteomics from Discovery to Function" held at the Indian Institute of Technology, Bombay from December 7-9, 2014. The panel discussed various challenges related to metabolomics and also proposed several effective solutions for optimum implementation of metabolomics in clinical practice. The key areas of panel discussion were improvement in metabolite databases with comprehensive spectral libraries, need for extensive bioinformatics tools for integrative approaches and serious considerations for clinical validation of the biomarkers for the successful implementation of metabolomics in clinics. Biological significance Information drafted in this report is significant for researchers working in metabolomics field to overcome the challenges and successful implementation of metabolomics in clinical practice. This article is part of a special issue titled: Proteomics in India. (C) 2015 Elsevier B.V. All rights reserved.
 
Publisher ELSEVIER SCIENCE BV
 
Date 2016-01-15T04:28:07Z
2016-01-15T04:28:07Z
2015
 
Type Article
 
Identifier JOURNAL OF PROTEOMICS, 127(A,SI)73-79
1874-3919
1876-7737
http://dx.doi.org/10.1016/j.jprot.2015.04.024
http://dspace.library.iitb.ac.in/jspui/handle/100/17757
 
Language en