Diversity-oriented approach to spirooxindoles: application of a green reagent 'rongalite'
DSpace at IIT Bombay
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Title |
Diversity-oriented approach to spirooxindoles: application of a green reagent 'rongalite'
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Creator |
KOTHA, S
ALI, R |
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Subject |
RING-CLOSING METATHESIS
DIELS-ALDER REACTION AMINO-ACID DERIVATIVES ASYMMETRIC TOTAL-SYNTHESIS ONE-POT SYNTHESIS KEY STEPS DIASTEREOSELECTIVE SYNTHESIS SYNTHETIC APPLICATIONS MOLECULAR FRAMEWORKS COUPLING REACTIONS 1,2,4,5-Tetrakis(bromomethyl)benzene Diels-Alder chemistry Rongalite Spirooxindole Sultine derivatives |
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Description |
A range of functionalized spirooxindole derivatives have been assembled via the Diels-Alder (DA) reaction. Here, rongalite has been used to generate the key sultine building blocks which are useful latent diene equivalents in the DA chemistry. The di-bromo intermediates used here are produced by reacting the 1,2,4,5-tetrakis(bromomethyl)benzene with protected oxindole derivatives under operationally simple reaction conditions. In our study, we avoided the isolation of various intermediates, and thus reduced the cost and efforts related to the overall process. (C) 2015 Elsevier Ltd. All rights reserved.
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Publisher |
PERGAMON-ELSEVIER SCIENCE LTD
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Date |
2016-01-15T05:55:35Z
2016-01-15T05:55:35Z 2015 |
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Type |
Article
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Identifier |
TETRAHEDRON LETTERS, 56(26)3992-3995
0040-4039 http://dx.doi.org/10.1016/j.tetlet.2015.04.095 http://dspace.library.iitb.ac.in/jspui/handle/100/17868 |
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Language |
en
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