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Versatile, Reversible, and Reusable Gel of a Monocholesteryl Conjugated Calix[4]arene as Functional Material to Store and Release Dyes and Drugs Including Doxorubicin, Curcumin, and Tocopherol

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Title Versatile, Reversible, and Reusable Gel of a Monocholesteryl Conjugated Calix[4]arene as Functional Material to Store and Release Dyes and Drugs Including Doxorubicin, Curcumin, and Tocopherol
 
Creator BANDELA, AK
HINGE, VK
YARRAMALA, DS
RAO, CP
 
Subject SUPRAMOLECULAR GELS
ORGANIC LIQUIDS
WATER GELATION
ORGANOGELS
GELATORS
CALIXARENE
ACID
FLUORESCENCE
DERIVATIVES
ASSEMBLIES
monocholesteryl derivatized calix[4]arene
material storage and release
drug encapsulation and release
AFM and SEM
molecular modeling
 
Description Gels are interesting soft materials owing to their functional properties leading to potential applications. This paper deals with the synthesis of monocholesteryl derivatized calix[4]arene (G) and its instantaneous gelation at a minimum gelator concentration of 0.6% in 1:1 v/v THF/acetonitrile. The gel shows remarkable thermoreversibility by exhibiting T-gel -> sol at similar to 48 degrees C and is demonstrated for several cycles. The gel shows an organized network of nanobundles, while that of the sol shows spherical nanoaggregates in microscopy. A bundle with similar to 12 nm diameter possessing hydrophobic pockets in itself is obtained from computationally modeled gel, and hence the gel is suitable for storage and release applications. The guest-entrapped gels exhibit the same Microstructures as that observed with simple gels, while fluorescence spectra and molecular mechanics suggests that the drug molecules occupy the hydrophobic pockets. All the entrapped drug molecules are released into water, suggesting a complete recovery of the trapped species. The reusability of the gel for the storage and release of the drug into water is demonstrated for four consecutive cycles, and hence the gel formed from G acts as a functional material that finds application in drug delivery.
 
Publisher AMER CHEMICAL SOC
 
Date 2016-01-15T06:17:28Z
2016-01-15T06:17:28Z
2015
 
Type Article
 
Identifier ACS APPLIED MATERIALS & INTERFACES, 7(21)11555-11566
1944-8244
http://dx.doi.org/10.1021/acsami.5b02506
http://dspace.library.iitb.ac.in/jspui/handle/100/17911
 
Language en