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Polymer Stabilized Fe3O4-Graphene as an Amphiphilic Drug Carrier for Thermo-Chemotherapy of Cancer

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Title Polymer Stabilized Fe3O4-Graphene as an Amphiphilic Drug Carrier for Thermo-Chemotherapy of Cancer
 
Creator SWAIN, AK
PRADHAN, L
BAHADUR, D
 
Subject GRAPHENE OXIDE
BIOMEDICAL APPLICATIONS
ANTICANCER DRUG
NANOPARTICLES
DELIVERY
THERAPY
PH
RELEASE
CELLS
COMPOSITE
cancer
drug carrier
graphene
iron oxide
stability
thermo-chemotherapy
 
Description In light of the growing interest in the search for cheap and effective solutions for cancer treatment, we report a simple one pot synthesis of polymer stabilized iron oxide-graphene (PIG) that could be realized on a large scale. The structural (Fe3O4 particle size of similar to 11 nm), functional (various oxygen containing moieties), and magnetic (moment of similar to 43 emu/g) properties of PIG are explored using various characterization techniques for possible biomedical applications. PIG shows good colloidal stability and is biocompatible even at higher concentrations (2.5 mg/mL) by virtue of cross-linking polymers. The biocompatibility of the composite has been tested using HeLa cell lines by computing the percentage of the reactive oxygen species through the 2,7-dichlorofluorescein (DCF) intensity level. PIG has the ability to load and release both hydrophobic and hydrophilic drugs with a good loading efficiency and capacity. The dug loading efficiency of PIG is measured to be similar to 87% and similar to 91% for doxorubicin (DOX) and paclitaxel (PTXL), respectively. Under an AC magnetic field, superparamagnetic PIG (2.5 mg/mL) takes less than 16 min to reach the stable hyperthermia temperature, suggesting it as a good anticancer material. A time-dependent cellular uptake of doxorubicin-conjugated PIG has been studied to optimize the parameters for thermo-chemotherapy of cancer. The synergetic effect of both the drug and hyperthermia is observed in the killing of the cancerous cells, verified by computing the cell apoptotic population using a flow cytometer. However, it has been noticed that, even in the absence of chemotherapy, PIG shows good antiproliferative activity with thermotherapy alone.
 
Publisher AMER CHEMICAL SOC
 
Date 2016-01-15T06:17:58Z
2016-01-15T06:17:58Z
2015
 
Type Article
 
Identifier ACS APPLIED MATERIALS & INTERFACES, 7(15)8013-8022
1944-8244
http://dx.doi.org/10.1021/acsami.5b02536
http://dspace.library.iitb.ac.in/jspui/handle/100/17912
 
Language en