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Engineering Micro/Nanoparticles by PPRGEL Process through Parametric Analysis

DSpace at IIT Bombay

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Field Value
 
Title Engineering Micro/Nanoparticles by PPRGEL Process through Parametric Analysis
 
Creator MONDAL, M
ROY, S
MUKHOPADHYAY, M
 
Subject CRYSTAL-GROWTH
CARBON-DIOXIDE
SUPERCRITICAL ANTISOLVENT
SECONDARY NUCLEATION
CO2-EXPANDED LIQUIDS
KINETICS
PARTICLES
SUPERSATURATION
REDUCTION
VOLUMES
 
Description The present work investigates the formation of micro/nanoparticles by precipitation by pressure reduction of gas-expanded liquid (PPRGEL) using carbon dioxide (CO2). Rapid depressurization of the GEL solution results in very rapid evolution of CO2 bubbles and a concomitant large temperature drop (similar to 50-70 K). Consequently, the solid solubility is lowered, leading to heterogeneous nucleation at the CO2 bubble-GEL interface. A thermodynamic model based on the total entropy change of the depressurizing system is used for computing the time-variant reduction of the CO2 mole fraction in GEL for the CO2-acetone-cholesterol system. This, in turn, is used in a combination with a kinetic model for predicting the variation of nucleation rate and the resultant solute particle size. The model is used to analyze the effects of the pre-depressurization pressure and the depressurization time, the key process parameters, on the average particle size. The predicted particle size compares well with reported experimental data.
 
Publisher AMER CHEMICAL SOC
 
Date 2016-01-15T06:26:37Z
2016-01-15T06:26:37Z
2015
 
Type Article
 
Identifier INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 54(13)3451-3461
0888-5885
http://dx.doi.org/10.1021/ie504960u
http://dspace.library.iitb.ac.in/jspui/handle/100/17929
 
Language en