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PEGylated FePt-Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS)

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Title PEGylated FePt-Fe3O4 composite nanoassemblies (CNAs): in vitro hyperthermia, drug delivery and generation of reactive oxygen species (ROS)
 
Creator SAHU, NK
GUPTA, J
BAHADUR, D
 
Subject MAGNETIC NANOPARTICLES
THERAPEUTIC APPLICATIONS
SYSTEM
CANCER
POLYMERS
CLUSTERS
RELEASE
DESIGN
OXIDE
 
Description Chemothermal therapy is widely used in clinical applications for the treatment of tumors. However, the major challenge is the use of a multifunctional nano platform for significant regression of the tumor. In this study, a simple synthesis of highly aqueous stable, carboxyl enriched, PEGylated mesoporous iron platinum-iron(II, III) oxide (FePt-Fe3O4) composite nanoassemblies (CNAs) by a simple hydrothermal approach is reported. CNAs exhibit a high loading capacity similar to 90 wt% of the anticancer therapeutic drug, doxorubicin (DOX) because of its porous nature and the availability of abundant negatively charged carboxylic groups on its surface. DOX loaded CNAs (CNAs + DOX) showed a pH responsive drug release in a cell-mimicking environment. Furthermore, the release was enhanced by the application of a alternating current magnetic field. CNAs show no appreciable cytotoxicity in mouse fibroblast (L929) cells but show toxic effects in cervical cancer (HeLa) cells at a concentration of similar to 1 mg mL(-1). A suitable composition of CNAs with a concentration of 2 mg mL(-1) can generate a hyperthermic temperature of similar to 43 degrees C. Also, CNAs, because of their Fe and Pt contents, have an ability to generate reactive oxygen species (ROS) in the presence of hydrogen peroxide inside the cancer cells which helps to enhance its therapeutic effects. The synergistic combination of chemotherapy and ROS is very efficient for killing cancer cells.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2016-01-15T06:50:05Z
2016-01-15T06:50:05Z
2015
 
Type Article
 
Identifier DALTON TRANSACTIONS, 44(19)9103-9113
1477-9226
1477-9234
http://dx.doi.org/10.1039/c4dt03470h
http://dspace.library.iitb.ac.in/jspui/handle/100/17975
 
Language en