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Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines
DSpace at IIT Bombay
View Archive Info| Field | Value | |
| Title |
Naphthoquinone-based chalcone hybrids and derivatives: synthesis and potent activity against cancer cell lines
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| Creator |
JARDIM, GAM
GUIMARAES, TT PINTO, MDFR CAVALCANTI, BC DE FARIAS, KM PESSOA, C GATTO, CC NAIR, DK NAMBOOTHIRI, INN DA SILVA, EN |
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| Subject |
LAPACHONE-BASED 1,2,3-TRIAZOLES
NOR-ALPHA-LAPACHONE BETA-LAPACHONE HETEROCYCLIC-DERIVATIVES ANTIMALARIAL ACTIVITY ANTITUMOR-ACTIVITY TRYPANOSOMA-CRUZI CYTOTOXICITY AGENTS INHIBITORS |
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| Description |
Novel naphthoquinone-based chalcones were prepared from the reaction between 3-bromo-nor-beta-lapachone and amino-chalcones. Lapachone derivatives are also described here. All the substances were evaluated against cancer and normal cell lines and several compounds demonstrated potent antitumor activity.
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| Publisher |
ROYAL SOC CHEMISTRY
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| Date |
2016-01-15T06:53:09Z
2016-01-15T06:53:09Z 2015 |
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| Type |
Article
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| Identifier |
MEDCHEMCOMM, 6(1)120-130
2040-2503 2040-2511 http://dx.doi.org/10.1039/c4md00371c http://dspace.library.iitb.ac.in/jspui/handle/100/17981 |
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| Language |
en
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