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Iron oxide nanorods as high-performance magnetic resonance imaging contrast agents

DSpace at IIT Bombay

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Title Iron oxide nanorods as high-performance magnetic resonance imaging contrast agents
 
Creator MOHAPATRA, J
MITRA, A
TYAGI, H
BAHADUR, D
ASLAM, M
 
Subject MRI CONTRAST
FE3O4 NANOPARTICLES
BETA-FEOOH
GROWTH
HYPERTHERMIA
OLEYLAMINE
DIAGNOSIS
THERAPY
FACILE
FE
 
Description An efficient magnetic resonance imaging (MRI) contrast agent with a high R-2 relaxivity value is achieved by controlling the shape of iron oxide to rod like morphology with a length of 30-70 nm and diameter of 4-12 nm. Fe3O4 nanorods of 70 nm length, encapsulated with polyethyleneimine show a very high R-2 relaxivity value of 608 mM(-1) s(-1). The enhanced MRI contrast of nanorods is attributed to their higher surface area and anisotropic morphology. The higher surface area induces a stronger magnetic field perturbation over a larger volume more effectively for the outer sphere protons. The shape anisotropy contribution is understood by calculating the local magnetic field of nanorods and spherical nanoparticles under an applied magnetic field (3 Tesla). As compared to spherical geometry, the induced magnetic field of a rod is stronger and hence the stronger magnetic field over a large volume leads to a higher R-2 relaxivity of nanorods.
 
Publisher ROYAL SOC CHEMISTRY
 
Date 2016-01-15T07:12:58Z
2016-01-15T07:12:58Z
2015
 
Type Article
 
Identifier NANOSCALE, 7(20)9174-9184
2040-3364
2040-3372
http://dx.doi.org/10.1039/c5nr00055f
http://dspace.library.iitb.ac.in/jspui/handle/100/18020
 
Language en