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A concise protecting-group-free synthesis of cephalosporolides E and F
DSpace at IIT Bombay
View Archive Info| Field | Value | |
| Title |
A concise protecting-group-free synthesis of cephalosporolides E and F
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| Creator |
CHAUDHARI, DA
KATTANGURU, P FERNANDES, RA |
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| Subject |
MARINE-DERIVED FUNGUS
PENICILLIUM-SP LACTONES |
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| Description |
A concise protecting-group-free synthesis of cephalosporolides E and F has been described. The key steps involve the one-pot conversion of L-mannonic-gamma-lactone to gamma-vinyl-beta-hydroxy-gamma-lactone, cross-metathesis and Wacker-type oxidative spiroketalization. The internal olefin served as a latent keto functionality with excellent delivery of a regioselective keto group for spiroketalization. The synthetic strategy is protecting-group-free and marks the shortest route so far to cephalosporolides E and F.
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| Publisher |
ROYAL SOC CHEMISTRY
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| Date |
2016-01-15T07:21:08Z
2016-01-15T07:21:08Z 2015 |
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| Type |
Article
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| Identifier |
RSC ADVANCES, 5(52)42131-42134
2046-2069 http://dx.doi.org/10.1039/c5ra06991b http://dspace.library.iitb.ac.in/jspui/handle/100/18036 |
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| Language |
en
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