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Passive blood plasma separation at the microscale: a review of design principles and microdevices

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Title Passive blood plasma separation at the microscale: a review of design principles and microdevices
 
Creator TRIPATHI, S
KUMAR, YVBV
PRABHAKAR, A
JOSHI, SS
AGRAWAL, A
 
Subject RED-CELL DISTRIBUTION
WHOLE HUMAN BLOOD
DRIVEN MICROFLUIDIC DEVICE
ON-A-CHIP
CROSS-FLOW
FREE LAYER
MICROVASCULAR BIFURCATIONS
APPARENT VISCOSITY
RAPID SEPARATION
MICROCHANNEL
hydrodynamic
geometrical effects
bio-physical effects
sedimentation
microfiltration
microfluidics
 
Description Blood plasma separation is vital in the field of diagnostics and health care. Due to the inherent advantages obtained in the transition to microscale, the recent trend in these fields is a rapid shift towards the miniaturization of complex macro processes. Plasma separation in microdevices is one such process which has received extensive attention from researchers globally. Blood plasma separation techniques based on microfluidic platforms can be broadly classified into two categories. While active techniques utilize external force fields for separation, the passive techniques are dependent on biophysical effects, cell behavior, hydrodynamic forces and channel geometry for blood plasma separation. In general, passive separation methods are favored in comparison to active methods because they tend to avoid design complexities and are relatively easy to integrate with biosensors; additionally they are cost effective. Here we review passive separation techniques demonstrating separation and blood behavior at microscale. We present an extensive review of relevant biophysical laws, along with experimental details of various passive separation techniques and devices exploiting these physical effects. The relative performances, and the advantages and disadvantages of microdevices discussed in the literature, are compared and future challenges are brought about.
 
Publisher IOP PUBLISHING LTD
 
Date 2016-01-15T08:20:07Z
2016-01-15T08:20:07Z
2015
 
Type Article
 
Identifier JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 25(8)
0960-1317
1361-6439
http://dx.doi.org/10.1088/0960-1317/25/8/083001
http://dspace.library.iitb.ac.in/jspui/handle/100/18149
 
Language en