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Sensing of Stimulus Artifact Suppressed Signals From Electrode Interfaces

DSpace at IIT Bombay

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Field Value
 
Title Sensing of Stimulus Artifact Suppressed Signals From Electrode Interfaces
 
Creator NAG, S
SIKDAR, SK
THAKOR, NV
RAO, VR
SHARMA, D
 
Subject ELECTRICAL-STIMULATION
SYSTEM
AMPLIFIER
REMOVAL
POTENTIALS
CULTURES
LOOP
Stimulus artifact suppression
biphasic constant current stimulator
electrode-electrolyte interface
instrumentation and differential amplifier
 
Description Stimulus artifacts inhibit reliable acquisition of biological evoked potentials for several milliseconds if an electrode contact is utilized for both electrical stimulation and recording purposes. This hinders the measurement of evoked short-latency biological responses, which is otherwise elicited by stimulation in implantable prosthetic devices. We present an improved stimulus artifact suppression scheme using two electrode simultaneous stimulation and differential readout using high-gain amplifiers. Substantial reduction of artifact duration has been shown possible through the common-mode rejection property of an instrumentation amplifier for electrode interfaces. The performance of this method depends on good matching of electrode-electrolyte interface properties of the chosen electrode pair. A novel calibration algorithm has been developed that helps in artificial matching of impedance and thereby achieves the required performance in artifact suppression. Stimulus artifact duration has been reduced down to 50 mu s from the stimulation-cum-recording electrodes, which is similar to 6x improvement over the present state of the art. The system is characterized with emulated resistor-capacitor loads and a variety of in-vitro metal electrodes dipped in saline environment. The proposed method is going to be useful for closed-loop electrical stimulation and recording studies, such as bidirectional neural prosthesis of retina, cochlea, brain, and spinal cord.
 
Publisher IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
 
Date 2016-01-15T08:56:27Z
2016-01-15T08:56:27Z
2015
 
Type Article
 
Identifier IEEE SENSORS JOURNAL, 15(7)3734-3742
1530-437X
1558-1748
http://dx.doi.org/10.1109/JSEN.2015.2399248
http://dspace.library.iitb.ac.in/jspui/handle/100/18216
 
Language en