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A simple approach to bis-spirocycles and spiroindole derivatives via green methods such as Fischer indolization, ring-closing metathesis, and Suzuki-Miyaura cross-coupling

DSpace at IIT Bombay

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Title A simple approach to bis-spirocycles and spiroindole derivatives via green methods such as Fischer indolization, ring-closing metathesis, and Suzuki-Miyaura cross-coupling
 
Creator KOTHA, S
ALI, R
 
Subject DIVERSITY-ORIENTED APPROACH
OLEFIN METATHESIS
CLAISEN REARRANGEMENT
INDOLE ALKALOIDS
NATURAL-PRODUCTS
CATALYSTS
FUNCTIONALIZATION
CHEMISTRY
LIGANDS
DESIGN
Spirocycles
Fischer indolization
ring-closing metathesis
Suzuki coupling
Grubbs' catalyst
 
Description We have developed a simple synthetic methodology for bis-spirocycles and spiroindole derivatives starting with a commercially available 6-bromo-2-tetralone. Here, we have used Fischer indolization, ring-closing metathesis, and Suzuki Miyaura cross-coupling as key steps to assemble a variety of spirocyclic frameworks. The methodology developed here is simple and it may be useful to prepare various spirocycles containing indole moiety.
 
Publisher SCIENTIFIC TECHNICAL RESEARCH COUNCIL TURKEY-TUBITAK
 
Date 2016-01-15T10:40:47Z
2016-01-15T10:40:47Z
2015
 
Type Article
 
Identifier TURKISH JOURNAL OF CHEMISTRY, 39(6)1190-1198
1300-0527
http://dx.doi.org/10.3906/kim-1502-116
http://dspace.library.iitb.ac.in/jspui/handle/100/18371
 
Language en