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Diversity-oriented approach to spirocycles with indole moiety via Fischer indole cyclization, olefin metathesis and Suzuki-Miyaura cross-coupling reactions

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Title Diversity-oriented approach to spirocycles with indole moiety via Fischer indole cyclization, olefin metathesis and Suzuki-Miyaura cross-coupling reactions
 
Creator KOTHA, S
ALI, R
SRINIVAS, V
KRISHNA, NG
 
Subject RING-CLOSING METATHESIS
CLAISEN REARRANGEMENT
KEY STEPS
NATURAL-PRODUCTS
CYCLOPHANE DERIVATIVES
STRATEGIC UTILIZATION
MOLECULAR FRAMEWORKS
CATALYZED REACTIONS
ARYLBORONIC ACIDS
ORGANIC-SYNTHESIS
Spirocycles
Claisen rearrangement
Fischer indole cyclization
Ring-closing metathesis
Suzuki Miyaura cross-coupling
 
Description A range of aryl substituted spirocycles containing the indole moiety have been assembled through Claisen rearrangement, Fischer indole cyclization, ring-closing metathesis and the Suzuki-Miyaura cross-coupling reactions. Some of these molecules contain either a spirocyclic system or an indeno[1,2-b] indole framework, which is present in diverse bioactive targets. Here, we have used simple and readily available starting materials to generate a library of spirocycles with an indole unit in their structures. (C) 2014 Elsevier Ltd. All rights reserved.
 
Publisher PERGAMON-ELSEVIER SCIENCE LTD
 
Date 2016-01-15T10:52:52Z
2016-01-15T10:52:52Z
2015
 
Type Article
 
Identifier TETRAHEDRON, 71(1)129-138
0040-4020
http://dspace.library.iitb.ac.in/jspui/handle/100/18395
 
Language en