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Alterations in immune responses induced by selective modification in env gene of HIV-1 subtype C from India

Shodhganga@INFLIBNET

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Title Alterations in immune responses induced by selective modification in env gene of HIV-1 subtype C from India
 
Contributor Tripathy, S P
Khandekar, P
 
Subject Molecular Virology
 
Description HIV-1, like many other viruses, is surrounded by a lipid membrane from which protrudes a virally encoded type I membrane protein, envelope (Env). The Env is initially synthesized as a single polypeptide precursor which gets cleaved by cellular proteases into a surface subunit, gp120 that remains non-covalently attached to a transmembrane domain subunit, gp41. The primary receptor for HIV-1 is the CD4 antigen, to which the gp120 subunit of Env binds. This causes structural alterations in gp120, enabling it to bind subsequently to a second receptor, termed a co receptor and this binding gives the final trigger that leads to membrane fusion. The HIV-1 Env protein is the target of virus-neutralizing antibodies (NAbs), but it does not normally elicit a strong NAb response in infected individuals. Most of these antibodies elicited against the HIV-1 Env during natural infection or after vaccination are incapable of neutralizing HIV-1 infectivity in vitro. While several such antibodies effectively neutralize viruses that are adapted to replicate in immortalized T-cell lines (TCLA strains). HIV has ability to evade the immune system, which has been associated with the rapid variability of the HIV env sequence and the masking of epitopes by glycosylation. Three mechanisms can contribute to the escape from NAbs: point mutations, changes in glycosylation patterns, and insertions and deletions in the HIV Env. HIV-1 Env is a highly glycosylated protein.
Abstract includes, References p.217-245
 
Date 2011-08-17T12:15:29Z
2011-08-17T12:15:29Z
2011-08-17
0
May, 2008
2008
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/2237
 
Language English
 
Rights university
 
Format 245p.
DVD
 
Publisher Pune
University of Pune
Department of Molecular Virology
 
Source INFLIBNET