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Design of toxicant imprinted polymers with high specificity and selectivity

Shodhganga@INFLIBNET

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Field Value
 
Title Design of toxicant imprinted polymers with high specificity and selectivity
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Contributor Mathew , Beena
 
Subject selectivity
molecular imprinting
monomer template ratio
crosslinking
nicotine
theophylline
caffeine
Scatchard plot
specificity
 
Description Molecularly imprinted polymers (MIPs) of a few substances that have toxicity at higher doses (nicotine, theophylline and caffeine) were prepared by bulk polymerization. To compare and analyse the binding efficiency of the MIPs, non-imprinted polymers (NIPs) were also prepared. Various spectroscopic methods such as FT-IR and 1H NMR were employed for analyzing pre-polymerisation solutions and for polymer characterization. Scanning electron microscopy gave the surface morphological differences between imprinted and non-imprinted polymers. Emphasis was given on the designing of imprinted polymers with maximum specificity and selectivity, by altering the nature and degree of crosslinking in the imprinted system as well as by observing the various parameters related to rebinding. The influence of different synthetic conditions such as nature of crosslinking agents, monomer-template ratio, extent of crosslinking and time of equilibrium on recognition properties of the polymers was investigated using UV-spectroscopic method. Scatchard analysis was done to evaluate the binding parameters of the imprinted polymers. The selectivity of MIPs was evaluated by rebinding the structurally similar compounds. The results indicated that the imprinted polymers exhibited an excellent selectivity towards the imprinted molecules.
References given chapters wise
 
Date 2013-02-26T06:27:30Z
2013-02-26T06:27:30Z
2013-02-26
n.d.
May 2007
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/7082
 
Language English
 
Relation -
 
Rights university
 
Format 157p.
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None
 
Coverage Chemistry
 
Publisher Kottayam
Mahatma Gandhi University
School Of Chemical Sciences
 
Source INFLIBNET