Record Details

Biological effects of feeding cuttle fish liver oil to rats

Shodhganga@INFLIBNET

View Archive Info
 
 
Field Value
 
Title Biological effects of feeding cuttle fish liver oil to rats
-
 
Contributor Sherief, P M
Nair, J Rajasekharan
 
Subject immune function
cuttlefish liver oil
atherogenesis
eicosapentaenoic acid
docosahexaenoic acid
cardioprotective
Biochemistry
 
Description The cuttlefish liver discarded during processing contains a high oil content (6- 40%) and is a rich source of and#969;-3 polyunsaturated fatty acids (and#969;-3 PUFAs) like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Feeding cuttlefish liver oil (CFLO) at 1% level to rats fed atherogenic diet (AD) for a period of 90 days, showed a lowering of gain in body weight and liver weight; lipid components in serum and tissues, LDL-cholesterol (LDL-C) and atherogenic ratio; increase in HDL-cholesterol (HDL-C), increased faecal excretion of bile acids and neutral sterols; decreased lipogenic enzyme activities, increased antioxidant enzyme activities and antioxidant levels, but, decreased levels of lipid peroxidation products in tissues. The antiatherogenic action of CFLO observed is through decreased lipogenesis, increased cholesterol transport to liver, enhanced excretion of neutral sterols and bile acids and above all a stimulated antioxidant defense system and this might be due to its high content of and#969;-3 PUFAs which in the presence of antioxidants (vitamins E and C and green tea flavonoids) offer greater effect. The cardioprotective action, immune function, inflammatory response and platelet aggregation was also studied by feeding 1 % CFLO for a period of 45 days. The study showed lowering of the levels of diagnostic marker enzymes, enhanced proliferation of spleen and bone marrow cells, increase in the number of plaque forming cells in the spleen and antibody titre in the circulation; inhibition of carrageenan induced acute paw oedema, formalin induced chronic paw oedema and adenosine diphosphate (ADP) induced platelet aggregation. The and#969;-3 PUFAs especially the EPA present in the CFLO may be responsible for the observed beneficial effects.
References p.122-150
 
Date 2013-02-27T06:49:12Z
2013-02-27T06:49:12Z
2013-02-27
n.d.
July, 2007
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/7113
 
Language English
 
Relation -
 
Rights university
 
Format 150p.
-
None
 
Coverage Biochemistry
 
Publisher Kottayam
Mahatma Gandhi University
School of Bio Sciences
 
Source INFLIBNET