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Design Synthesis Characterization Molecular Modelling and Biological Evaluation of Some Novel Antimalarial Agents

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Title Design Synthesis Characterization Molecular Modelling and Biological Evaluation of Some Novel Antimalarial Agents
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Contributor Dr. Gopal Garg
 
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Description The current interest in the creation of large searchable libraries of organic compounds has
newlinecaptured an imagination of organic chemist and the drug discovery community,considering the necessity for new and novel chemical inhibitors of biological functions.
newlineHere the basic objective to introduce chemical diversity in the molecular frame work of
newlinesome heterocyclic compounds, in order to synthesize pharmacologically interesting
newlineheterocyclic compounds. Synthesis, Characterization and looking to the application of
newlineheterocyclic compounds.
newlineIn this thesis we have carried out study to understand; showing an urgent need to
newlinediscover new antimalarials, due to the spread of chloroquine resistance and the limited
newlinenumber of available drugs. This thesis contains six chapters and brief description as
newlinefollows.
newlineChapter 1 Introduction
newlineMalaria, the most prevalent and most pernicious parasitic disease of humans, is estimated
newlineto kill about two million people, mainly children, each year. Several new drugs along
newlinewith chloroquine, the first synthetically developed antimalarial drug proved to be a
newlinesuccessful cure in the past 50 years. The emergence and spread of resistant parasites to
newlinesome of the drugs and their combination has made it virtually ineffective in most parts of
newlinethe world. And thus, it is indispensable to discover, design, and develop new drugs with
newlinedifferent mechanisms, with diversity in chemical structure and be efficacious against drug
newlineresistant strain. In addition to this it should be safe for children and pregnant women, and
newlinebe affordable. The ability to treat and control P. falciparum infection through
newlinechemotherapy has been compromised by the advent and spread of resistance to
newlineantimalarial drugs.
newlineABSTRACT
newlineSURESH GYAN VIHAR UNIVERSITY, JAIPUR IX
newlineChapter 2 Review of Literature
newlineThere are several targets validated for development of antimalarial agents. Falcipain is a
newlinecysteine protease enzyme, a validated target for malaria. Several studies confirmed the
newlineefficacy of cysteine protease inhibitors in arresting and killing para
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Date 2014-05-24T07:53:35Z
2014-05-24T07:53:35Z
2014-05-24
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03/03/2014
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/18620
 
Language English
 
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Rights university
 
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DVD
 
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Publisher Jaipur
Suresh Gyan Vihar University
Department of Pharmacy
 
Source University