Record Details

Identification of Genetic signatures in high altitude stress

Shodhganga@INFLIBNET

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Field Value
 
Title Identification of Genetic signatures in high altitude stress
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Contributor Saradhi, Pardha
 
Subject Environmental science
Acute Mountain Sickness
high altitude stress
genetic signatures
stress
Hypoxia sensing
 
Description Securing the country s borders is the fundamental requirement for maintaining sovereignty of any independent Nation. Army troops are positioned to high altitude like Siachen and Kargil sectors. Despite of adverse conditions (viz. reduced oxygen availability, UV radiations, high velocity dry, cold wind) positioning of soldiers in those areas is extremely important for security of the country. It is important that individuals of military and paramilitary forces posted at high altitude maintain good health and perform extremely well. However, it is well known that the potential to withstand and acclimatize to adverse multiple stress conditions prevailing at high altitude vary from individual to individual. Variation in genetic makeup and gene expression makes individuals to be either susceptible or tolerant to adverse environmental factors. The present investigations elaborates the comparison in gene expression patterns of sensitive sojourns acutely inducted to high altitude from tolerant control and high altitude natives. Blood from human volunteer donors were used for evaluating variation in gene expression. Human whole genome array 40K chips with single fluorescent dye Cy3 were used to study gene expression. It was possible to demonstrate for the first time that the genes for endothelin converting enzyme1, NADPH oxidase1, DnaJ (Hsp40), Hsp 90, IL11, carbonic anhydrase IX, tumor necrosis factor, acetoacetyl CoA synthetase etc. play a critical role in adaptation of individuals to the adverse conditions. Also, HAPE patients showed transcript abundance for genes involved in detoxification and drug metabolism (PEX10, CYP4A11), pyruvat6e metabolism (PDK1), lipid metabolism, carbohydrate metabolism, apoptosis, protein phosphorylation, DNA repair, cell proliferation, differentiation and inflammation. It is evident that alteration in gene expression profile may be critical for the system to acclimatize to hypoxia.
Bibliography p.154-180, Appendix p.181
 
Date 2013-12-04T05:32:27Z
2013-12-04T05:32:27Z
2013-12-04
n.d.
2012
n.d.
 
Type Ph.D.
 
Identifier http://hdl.handle.net/10603/13624
 
Language English
 
Relation -
 
Rights university
 
Format v,181p.
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None
 
Coverage Environmental science
 
Publisher New Delhi
University of Delhi
Dept. of Electronic Science
 
Source INFLIBNET