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Monitoring biosafety of pharmaceutical drugs, insecticides, and other bioactive molecules to mitochondria

OAR@ICRISAT

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Relation http://oar.icrisat.org/9584/
 
Title Monitoring biosafety of pharmaceutical drugs, insecticides, and other bioactive molecules to mitochondria
 
Creator Akbar, S M D
Sreeramulu, K
Sharma, H C
 
Subject Others
 
Description Mitochondria are large cell organelles in plant and animal cells. They convert chemical energy from food in the cell to usable energy using oxygen. This process is called oxidative phosphorylation, which takes place inside the mitochondria. Reactions of Krebs cycle produce a chemical, NADH (Nicotinamide Adenine Dinucleotide, reduced form), which is then used by enzymes present in the inner mitochondrial membrane to generate energy rich adenosine triphosphate (ATP) molecules. These molecules are utilized by the cells whenever energy is required. Therefore, mitochondria are also referred as power houses of the cell. Mitochondria are abundantly present in muscle and brain cells, and sperms to supply ATPs during demand for energy. Monitoring biosafety of pharmaceutical drugs, insecticides, and other bioactive molecules to mitochondria is necessary because some of them interact with the mitochondrial membrane or membrane proteins, thereby affecting the energy levels of cells or even induces mitochondrial-dependent apoptosis (programmed cell death).
 
Date 2016-06-18
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://oar.icrisat.org/9584/1/Atlas%20of%20Science.pdf
Akbar, S M D and Sreeramulu, K and Sharma, H C (2016) Monitoring biosafety of pharmaceutical drugs, insecticides, and other bioactive molecules to mitochondria. Atlas of Science. 01-03.