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New sterols with anti-inflammatory potentials against cyclooxygenase-2 and 5-lipoxygenase from Paphia malabarica

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Relation http://eprints.cmfri.org.in/11342/
https://www.ncbi.nlm.nih.gov/pubmed/27736157
 
Title New sterols with anti-inflammatory potentials
against cyclooxygenase-2 and 5-lipoxygenase from
Paphia malabarica
 
Creator Joy, Minju
Chakraborty, Kajal
Raola, Vamshi Krishna
 
Subject Fish Biotechnology
 
Description Marine bivalves occupy a leading share in the total edible molluscs
at the coastline regions of south-eastern Asia, and are found to
possess significant nutritional and biological potential. Various
in vitro evaluation (antioxidant and anti-inflammatory) guided
purification of ethyl acetate–methanol (EtOAc–MeOH) extract
of bivalve clam, Paphia malabarica characterised two new sterol
derivatives as 23-gem-dimethylcholesta-5-en-3β-ol (1) and (22E)-
241,242-methyldihomocholest-5,22-dien-3β-ol (2) collected from the
south-west coast of Arabian Sea. Their structures were unambiguously
assigned on the basis of 1D, 2D NMR spectroscopy and mass
spectrometry. The antioxidant and anti-inflammatory activities
of 2 as determined by DPPH/ABTS+ radical scavenging and anticyclooxygenase-
2/5-lipoxygenase assays were significantly greater
(IC50 < 1 mg/mL) than 1 (IC50 > 1 mg/mL). Structure–activity relationship
analysis revealed that the bioactivities of these compounds were
directly proportional to the electronic and lipophilic parameters. This
is the first report of the occurrence and characterisation of 23-gemdimethyl-
3β-hydroxy-Δ5-cholestane nucleus and C-30 dihomosterol
from marine organisms.
 
Publisher Taylor and Francis
 
Date 2017
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/11342/1/New%20sterols%20with%20anti%20inflammatory%20potentials%20from%20Paphia%20malabarica_Kajal%20Chakraborty_Natural%20Product%20Research_2017.pdf
Joy, Minju and Chakraborty, Kajal and Raola, Vamshi Krishna (2017) New sterols with anti-inflammatory potentials against cyclooxygenase-2 and 5-lipoxygenase from Paphia malabarica. Natural Product Research, 31. pp. 1286-1298. ISSN 1478-6427 (Online)