Record Details

A lipoxygenase inhibitor from Aspergillus niger

IR@CSIR-CFTRI

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Field Value
 
Relation http://ir.cftri.com/220/
AMB-07-02
 
Title A lipoxygenase inhibitor from Aspergillus niger
 
Creator Sekhar Rao, K. C.
Divakar, S.
Appu Rao, A. G.
Karanth, N. G.
 
Subject 04 Fermentation Technology
04 Fungi
 
Description

A lipoxygenase-1 (LOX-1) inhibitor was isolated from the fermented broth of Aspergillus niger
CFTRI 1105. It was purified, using column and preparative
thin layer chromatography. 1H NMR and GC-MS examination revealed the structure of the inhibitor to be 2-(22-methyl, 42-hydroxyphenyl), 2-(422hydroxyphenyl)-propane with a molecular weight of 242 and the molecular formula C16H18O2. This bisphenol-derivative inhibitor shows 50% inhibition of soybean LOX-1 at 0.98 mM concentration. The activity of this inhibitor was compared with commercial bisphenol A and its structural analogues,butylhydroxyanisole and butylhydroxytoluene in an attempt to understand the role of functional groups affecting lipoxygenase activity.
 
Date 2002-01
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/220/1/Applied_Microbiology_and_Biotechnology_58%282002%29_539-542.pdf
Sekhar Rao, K. C. and Divakar, S. and Appu Rao, A. G. and Karanth, N. G. (2002) A lipoxygenase inhibitor from Aspergillus niger. Applied Microbiology and Biotechnology, 58. pp. 539-542.