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Studies on the beneficial effects of dietary fiber on experimentally induced diabetic rats with particular emphasis on glomerular filtration matrix

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Title Studies on the beneficial effects of dietary fiber on experimentally induced diabetic rats with particular emphasis on glomerular filtration matrix
 
Creator Suresh Kumar, G.
 
Subject 08 Food technology
04 Diabetes Mellitus
 
Description Diabetes is a disease of great concern to many all over the world and is characterized by its complications such as diabetic neuropathy,retinopathy and nephropathy. Diabetic nephropathy leading to kidney damage is one of the serious concerns and has aroused lot of research interest. During diabetic nephropathy changes in glomerular basement
membrane (GBM) are known to take place making the glomeruli
thicker. The structure and composition of GBM is of importance for its function as filtration barrier in the glomerulus. The glomerular filtration matrix, which is essential for normal filtration to take place is formed of
heparan sulphate, type IV collagen and laminin. During diabetes thickening of GBM is known to take place due to reduction in heparan sulfate and laminin and accumulation of type IV collagen leading to abnormal filtration.
Dietary management of diabetes is now well established to be one of the means in the management of diabetes. In this category, dietary fibers and foods rich in dietary fibers are well accepted to have beneficial functions in the management of diabetes. But there are not many scientific investigations on the role of these dietary fibers in minimizing complications of diabetes, such as diabetic nephropathy. In recent years, fermentation of dietary fibers to short chain fatty acids (SCFA), such as
acetate, propionate and butyrate is being increasingly recognized to play beneficial functions in normal physiological condition and also in alleviating pathological conditions such as cancer, diabetes, etc. Our
laboratory has shown that butyric acid ameliorates diabetic and diabetic nephropathy state. Among the foods that possess beneficial effects on diabetes, dietary
fiber rich foods are one of the important classes. Spent turmeric, a byproduct of turmeric industry is one of the rich sources of dietary fibers.Hence, one of the objectives was to study the effects of dietary fiber rich food, spent turmeric, a by-product of curcumin industry, on diabetic
and diabetic nephropathy state with particular emphasis on
glycoconjugate metabolism in glomerular basement membrane.
 
Date 2005-07
 
Type Thesis
NonPeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/344/1/002.pdf
Suresh Kumar, G. (2005) Studies on the beneficial effects of dietary fiber on experimentally induced diabetic rats with particular emphasis on glomerular filtration matrix. Doctoral thesis, University of Mysore.