Record Details

Spray-dried milk supplemented with -linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats.

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/571/
http://www.sciencedirect.com/science/journal/0039128X
10.1016/j.steroids.2006.01.002
 
Title Spray-dried milk supplemented with -linolenic acid or
eicosapentaenoic acid and docosahexaenoic acid decreases
HMG Co A reductase activity and increases biliary secretion
of lipids in rats.
 
Creator Ramaprasad, T. R.
Srinivasan, K.
Baskaran, V.
Sambaiah, K.
Lokesh, B. R.
 
Subject 27 Dairy products
 
Description In our earlier study, we have shown that rats fed spray-dried milk containing α-linolenic acid (LNA 18:3 n-3) or eicosapentaenoic acid (EPA 20:5 n-3) and docosahexaenoic acid (DHA 22:6 n-3) had significantly lower amounts of serum and liver cholesterol. To evaluate the mechanism for hypocholesterolemic effect of n-3 fatty acids containing milk formulation, we fed male Wistar rats with spray-dried milk containing linseed oil (LSO) (source of LNA) or fish oil (FO) (source of EPA + DHA) for 8 weeks. Feeding n-3 fatty acid containing milk formulation lowered the hepatic 3-hydroxy-methylglutaryl coenzyme A (HMG Co A) activity by 17–22% compared to rats given control diet devoid of n-3 fatty acids. The cholesterol level in liver microsomes was found to be decreased by 16% and 20%, respectively, in LSO and FO containing formulation fed rats. The bile flow was enhanced to an extent of 19–23% in experimental groups compared to control animals. The biliary cholesterol and phospholipid secretion was increased to an extent of 49–55% and 140–146%, respectively, in rats fed n-3 fatty acid containing formulation. The increase in the total bile acids secretion in bile was mainly reflected on an increase in the levels of taurine conjugated bile acids. These results indicated that n-3 fatty acid containing spray-dried milk formulation would bring about the hypocholesterolemic effect by lowering HMG Co A reductase activity in liver and by increasing the secretion of bile constituents.
 
Date 2006
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/571/1/steroids_7_1_%28_2_0_0_6_%29_409-415.pdf
Ramaprasad, T. R. and Srinivasan, K. and Baskaran, V. and Sambaiah, K. and Lokesh, B. R. (2006) Spray-dried milk supplemented with -linolenic acid or eicosapentaenoic acid and docosahexaenoic acid decreases HMG Co A reductase activity and increases biliary secretion of lipids in rats. Steroids, 71 (5). pp. 409-415. ISSN 0039-128X