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Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets

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JNB_02_99
 
Title Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets
 
Creator Suresh Babu, Poda
Srinivasan, Krishnapura
 
Subject 05 Onion
13 Nutrition-Human
04 Diabetes Mellitus
 
Description Onion (Allium cepa) powder and capsaicin, the pungent principle of red pepper (Capsicum annum) were added
in the amounts of 3 g% and 15 mg%, respectively, to the diet of streptozotocin-induced diabetic Wistar rats for
8 weeks. The presence of renal lesions was assessed by the extent and quality of proteinuria and by the leaching
of renal tubular enzymes into the urine. Renal integrity was assessed by measuring the activities in the kidney
tissue of several key enzymes of carbohydrate metabolism and of polyol pathway, transaminases, and ATPases.
Data on enzymuria and proteinuria, activities of kidney ATPases present in diabetic patients, suggested that
dietary onion caused significant beneficial modulation of the progression of renal lesions in the diabetic rats.
These findings were also corroborated by histologic examination of kidney sections. Dietary capsaicin did not
have any favorable influence on renal pathology in diabetes. It is inferred that this beneficial ameliorating
influence of dietary onion on diabetic nephropathy may be mediated through onion’s ability to lower blood
cholesterol levels and to reduce lipid peroxidation.
 
Date 1999
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1224/1/J._Nutr._Biochem._10_477-483%2C_1999.pdf
Suresh Babu, Poda and Srinivasan, Krishnapura (1999) Renal lesions in streptozotocin-induced diabetic rats maintained on onion and capsaicin containing diets. Journal of Nutritional Biochemistry, 10. pp. 477-583.