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Modulatory effect of butyric acid—a product of dietary fiber fermentation in experimentally induced diabetic rats

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Relation http://ir.cftri.com/1226/
JNB_04_02
 
Title Modulatory effect of butyric acid—a product of dietary fiber fermentation in experimentally induced diabetic rats
 
Creator Chethan, M. Kumar
Rachappaji, K. S.
Nandini, Chilkunda D.
Sambaiah, Kari
Salimath, P. V.
 
Subject 13 Nutrition-Human
04 Diabetes Mellitus
01 Dietary Fiber
 
Description The effect of feeding of butyric acid on alleviation of diabetic status was studied. Diabetes was induced in rats using streptozotocin. Rats were fed with basal diet containing wheat bran (5%) as a source of insoluble dietary fiber and guar gum (2.5%) as a source of soluble dietary fiber. The experimental group received butyric acid at 250, 500 and 750 mg/kg body weight/day. The diabetic animals lost weight in spite of high diet consumption. The levels of water intake, urine output, urine sugar, fasting blood sugar increased during diabetic condition compared to control and these were reduced by nearly 20% in the fiber-fed diabetic group. Further supplementation of butyric acid at 500 mg/kg body weight/day ameliorated the diabetic status by nearly 40%. Urine sugar level during the diabetic state was reduced from 7.2 g/day to 3.6 g/day and fasting blood glucose from 270 mg/dl to 180 mg/dl. Butyric acid feeding at 500 mg/kg body weight/day was most effective in controlling the diabetic status.
 
Date 2002
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/1226/1/Journal_of_Nutritional_Biochemistry_13_%282002%29_522-527.pdf
Chethan, M. Kumar and Rachappaji, K. S. and Nandini, Chilkunda D. and Sambaiah, Kari and Salimath, P. V. (2002) Modulatory effect of butyric acid—a product of dietary fiber fermentation in experimentally induced diabetic rats. Journal of Nutritional Biochemistry, 13. pp. 522-527.