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Antioxidant activities of flavidin in different in vitro model systems

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BMC-01-04
 
Title Antioxidant activities of flavidin in different in vitro model systems
 
Creator Jayaprakasha, G. K.
Jagan Mohan Rao, L.
Sakariah, K. K.
 
Subject 18 Flavonoid Chemistry
32 Antioxidants
 
Description Flavidin was isolated from Orchidaceae species and purified by silica gel column chromatography. The structure was
identified using physical and spectral (1H, 13C NMR, and mass) data. Antioxidant potency of flavidin was investigated employing various established in vitro model systems viz., b-carotene-linoleate, 1,1-diphenyl-2-picryl hydrazyl (DPPH), phosphomolybdenum method, and scavenging of hydrogen peroxide methods. Flavidin showed very good antioxidant activity (90.2%) and almost equivalent
to that of BHA at 50ppm level by b-carotene-linoleate method. Radical scavenging activity of flavidin was compared with BHA at 5, 10, 20, and 40ppm concentration and flavidin showed more radical scavenging activity than BHA at all the tested concentrations. Furthermore, flavidin showed very good antioxidant capacity by the formation of phosphomolybdenum complex method. Besides this, flavidin showed effective hydrogen peroxide scavenging activity. The data obtained in the in vitro models clearly establish the antioxidant potency of flavidin. However, comprehensive studies need to be conducted to ascertain the in vivo safety of flavidin in experimental animal models. This is the first report on antioxidant activity of 9,10-dihydro-5H-phenanthro-(4,5 bcd)-pyrans/flavidin type of compounds.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1254/1/Bioorganic_%26_Medicinal_Chemistry_12_%282004%29_5141-5146.pdf
Jayaprakasha, G. K. and Jagan Mohan Rao, L. and Sakariah, K. K. (2004) Antioxidant activities of flavidin in different in vitro model systems. Bioorganic and Medicinal Chemistry, 12. pp. 5141-5146.