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Enhancement in antimicrobial activity of 2-(phenyl)-3- (2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine

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Relation http://ir.cftri.com/1255/
BMCL-01-05
 
Title Enhancement in antimicrobial activity of 2-(phenyl)-3-
(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine
 
Creator Sadashiva, M. P.
Mallesha, H.
Karunakara Murthy, K.
Rangappa, K. S.
 
Subject 12 Microbial Biochemistry
 
Description The trans rich isomer, 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine A (>96% ee) was synthesized by the condensation of E isomer rich nitrone 4 (>98% ee) with butyl acrylate in an inert solvent. Obtained isoxazolidine was screened for its antifungal activity against Aspergillus niger, Cephalosporium acremonium, Fusarium moniliforme by using Nystatin
as positive control. It was also tested for its antibacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus by using Streptomycin as positive control. Enhanced antifungal activity was observed in isoxazolidine of >96% ee compared
to the isoxazolidine of >69% ee (B), and enhancement was not observed in antibacterial activity.
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1255/1/Bioorganic_%26_Medicinal_Chemistry_Letters_15_%282005%29_1811-1814.pdf
Sadashiva, M. P. and Mallesha, H. and Karunakara Murthy, K. and Rangappa, K. S. (2005) Enhancement in antimicrobial activity of 2-(phenyl)-3- (2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine. Bioorganic and Medicinal Chemistry Letters, 15. pp. 1811-1824.