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Stereoselective Hydrogenation of Thymol over Rh/alumina in the Presence of beta-cyclodextrin and its Derivatives

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Relation http://ir.cftri.com/1280/
JIP-02-01
 
Title Stereoselective Hydrogenation of Thymol over Rh/alumina in the Presence of
beta-cyclodextrin and its Derivatives
 
Creator Ravi, Palaniswamy
Divakar, S.
 
Subject 03 Essential oils
 
Description Stereoselective hydrogenation of thymol over Rh/alumina in the presence of various equivalents of -cyclodextrin (-CD)
and its derivatives in the solid state was studied. Hydrogenation of thymol in the absence of -CD gave 76.8% epimeric
alcohols with a menthol/neomenthol (M/N) ratio of 5.6 and an alcohol/ketone ratio of 4.5, whereas the presence of 0.1
equivalent (to thymol) of -CD gave rise to 94.6% of epimeric alcohols with a M/N ratio of 6.3 and an alcohol/ketone ratio
of 45.4. The effect of -cyclodextrin and its derivatives on the modification of the yield and the proportion of epimeric
alcohols formed were found to be the salient features of this investigation. Inclusion complexation of thymol by -CD
studied by UV-Visible spectroscopy indicated a 2 : 1 stoichiometry of thymol: -CD complex with a binding constant value
of 480 40 M−2.
 
Date 2001
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/1280/1/Journal_of_Inclusion_Phenomena_and_Macrocyclic_Chemistry_39_27-.pdf
Ravi, Palaniswamy and Divakar, S. (2001) Stereoselective Hydrogenation of Thymol over Rh/alumina in the Presence of beta-cyclodextrin and its Derivatives. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 39. pp. 27-33.