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Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil.

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Relation http://ir.cftri.com/2001/
FCT-02-05
 
Title Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil.
 
Creator Prasanthi, K.
Muralidhara, Dr.
Rajini, P. S.
 
Subject 26 Pesticide Chemistry
 
Description The primary objective of this study was to investigate the propensity of Fenvalerate (FEN), a synthetic pyrethroid to induce oxidative stress (OS) in various tissues of growing male rats following a short-term (28 days) dietary regimen and its possible attenuation by dietary (10%) sesame oil (SO). FEN incorporated diet was fed to weanling male rats at the dosages of 0, 250, 500 and 1000 ppm. Terminally, significant induction of OS in liver, thymus, spleen and erythrocytes was noticed at higher doses as evidenced by the elevated levels of lipid peroxidation (LPO). Significant dose-dependent depletion of GSH levels, perturbations in antioxidant enzymes, and enhanced protein carbonyls further confirmed the potential of FEN to induce OS in hepatic tissue. In addition, FEN also caused significant increases in activities of hepatic transaminases, ALP and LDH. Interestingly, dietary SO significantly attenuated FEN-induced oxidative damage in liver and other tissues. The degree of protection was remarkably high, since LPO and GSH status, protein carbonyl content and antioxidant defenses in liver and other tissues were brought down to basal levels in the SO + FEN1ooo group. These results clearly indicate the potential of FEN to induce oxidative damage in vivo and also suggest the ability of SO, a dietary fat to significantly offset the oxidative damage which may related to the presence of antioxidant compounds in the oil.
 
Date 2005
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/2001/1/Food_and_Chemical_Toxicology_43%282005%29_299-306.pdf
Prasanthi, K. and Muralidhara, Dr. and Rajini, P. S. (2005) Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil. Food and chemical toxicology , 43 (2). pp. 299-306. ISSN 0278-6915