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Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease.

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Title Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease.
 
Creator Muralidhar Hegde, L.
Shanmugavelu, Ponnuswamy
Vengamma, Bhuma
Sathyanarayana Rao, T. S.
Rani, B. Menon
Ranganath Rao, V.
Jagannatha Rao, K. S.
 
Subject 12 Metabolism
 
Description Trace elements have been postulated to play a role in Parkinson's disease (PD). In order to elucidate whether changes in the serum levels of trace elements reflect the progression of PD, we assessed serum levels of 12 elements (Na, K, Fe, Al, Cu, Zn, Ca, Mg, Mn, Si, P and S) in early PD, severe PD and normal subjects, using inductively coupled plasma atomic emission spectrometry. The concentrations in micromol/ml, the relative mole percentage distribution and inter-element relations were computed. Statistical analysis of these data showed a definite pattern of variation among certain elements in early and severe PD compared to controls. In both early and severe PD serum, Al and S concentrations were significantly decreased (p
 
Date 2004
 
Type Article
NonPeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/2008/1/Journal%20of%20Trace%20Elements%20in%20Medicine%20and%20Biology%2C%20Volume%2018%2C%20Issue%202%2C%2013%20December%202004%2C%20Pages%20163-171.pdf
Muralidhar Hegde, L. and Shanmugavelu, Ponnuswamy and Vengamma, Bhuma and Sathyanarayana Rao, T. S. and Rani, B. Menon and Ranganath Rao, V. and Jagannatha Rao, K. S. (2004) Serum trace element levels and the complexity of inter-element relations in patients with Parkinson's disease. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 18 (2). pp. 163-71. ISSN 0946-672X