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Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/2012/
Lipids-05-04
 
Title Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats.
 
Creator Ramaprasad, T. R.
Baskaran, V.
Sambaiah, K.
Lokesh, B. R.
 
Subject 17 Fatty Acid Chemistry
 
Description Indian diets comprising staples such as cereals, millets, and pulses provide 4.8 energy % from linoleic acid (18:2n-6) but fail to deliver adequate amounts of n-3 FA. Consumption of long-chain n-3 PUFA such as EPA (20:5n-3) and DHA (22:6n-3) is restricted to those who consume fish. The majority of the Indian population, however, are vegetarians needing additional dietary sources of n-3 PUFA. The present work was designed to use n-3 FA-enriched spray-dried milk powder to provide n-3 FA. Whole milk was supplemented with linseed oil to provide alpha-linolenic acid (LNA, 18:3n-3), with fish oil to provide EPA and DHA, or with groundnut oil (GNO), which is devoid of n-3 PUFA, and then spray-dried. Male Wistar rats were fed the spray-dried milk formulations for 60 d. The rats given formulations containing n-3 FA showed significant increases (P < 0.001) in the levels of LNA or EPA/DHA in the serum and in tissue lipids as compared with those fed the GNO control formulation. Rats fed formulations containing n-3 FA had 30-35% lower levels of serum total cholesterol and 25-30% lower levels of serum TAG than control animals. Total cholesterol and TAG in the livers of rats fed the formulations containing n-3 FA were lower by 18-30% and 11-18%, respectively, compared with control animals. This study showed that spray-dried milk formulations supplemented with n-3 FA are an effective means of improving dietary n-3 FA intake, which may decrease the risk factors associated with cardiovascular disease.
 
Date 2004
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/2012/1/Lipids_39%287%29_July_2004.pdf
Ramaprasad, T. R. and Baskaran, V. and Sambaiah, K. and Lokesh, B. R. (2004) Supplementation and delivery of n-3 fatty acids through spray-dried milk reduce serum and liver lipids in rats. Lipids, 39 (7). pp. 627-32. ISSN 0024-4201