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Sub chronic toxicity studies of lactulose in rats.

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Relation http://ir.cftri.com/2127/
IJEB-01-01
 
Title Sub chronic toxicity studies of lactulose in rats.
 
Creator Baskaran, V.
Murthy, K. N.
Dr., Mahadevamma
Vishwanatha, S.
Lokesh, B. R.
 
Subject 12 Allergy & Toxicology
 
Description Lactulose has profound health benefits by way of increasing bifidobacterial flora in the intestine of infants thereby protecting them against enteric infection, constipation and systemic encephalopathy. In the present study to assess the sub chronic toxicity of lactulose syrup, the rats were fed on a basal feed supplemented with lactulose syrup at 0.5, 1.0, 2.0 and 5.0% for a period of 21 weeks. Monitoring of food consumption, gain in body weight and physical observations did not reveal any treatment-related toxicity in any of the group of rats. Terminal autopsy also did not reveal any signs of toxicity. Further, no significant alterations in relative organ weight, serum biochemistry and urinalysis were observed up to 1% lactulose supplementation level. The results suggest that supplementation of lactulose in the diet does not produce any toxicity at the doses tested.
 
Date 2001
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/2127/1/Indian_Journal_of_Experimental_Biology_2001_39_441-446.pdf
Baskaran, V. and Murthy, K. N. and Dr., Mahadevamma and Vishwanatha, S. and Lokesh, B. R. (2001) Sub chronic toxicity studies of lactulose in rats. Indian Journal of Experimental Biology, 39 (5). pp. 441-446. ISSN 0019-5189