Record Details

Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/2319/
ABB-06-92
 
Title Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]
 
Creator Srinivas, L.
Shalini, V. K.
Shylaja, M.
 
Subject 07 Turmeric
32 Antioxidants
 
Description Dietary spice components have been screened for their protective effect against reactive oxygen species (ROS)-induced, lipid peroxide-mediated membrane and DNA damage and mutagenecity. A new, water soluble, 5-kDa peptide--Turmerin--from turmeric (Curcuma longa) has been found to be an efficient antioxidant/DNA-protectant/antimutagen. Turmerin forms 0.1% of the dry weight of turmeric and is obtained in a crystalline form. It is a heat stable, noncyclic peptide containing 40 amino acid residues, with a blocked N-terminal and leucine at the C-terminal. It is insensitive to trypsin and pepsin, heat, and uv radiation. Turmerin contains three residues of methionine which are partly responsible for the antioxidant activity. Turmerin at 183 nM offers 80% protection to membranes and DNA against oxidative injury. ROS-induced arachidonate release and the mutagenic activity of t-butyl hydroperoxide are substantially inhibited by Turmerin. Tumerin is noncytotoxic up to milligram concentrations, as tested by Ames assay and in human lymphocytes.
 
Date 1992
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Identifier http://ir.cftri.com/2319/1/Archives_of_Biochemistry_and_Biophysics%2C_Volume_292%2C_Issue_2%2C_1_February_1992%2C_Pages_617-623.pdf
Srinivas, L. and Shalini, V. K. and Shylaja, M. (1992) Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]. Archives of Biochemistry and Biophysics, 292 (2). pp. 617-23. ISSN 0003-9861