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In vitro studies on the intestinal absorption of curcumin in rats.

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Relation http://ir.cftri.com/2418/
Tox-01-81
 
Title In vitro studies on the intestinal absorption of curcumin in rats.
 
Creator Vijayalakshmi, R.
Chandrashekara, N.
 
Subject 07 Turmeric
 
Description When everted sacs of rat intestines were incubated with 50--750 ~g of
curcumin in 10 ml incubation medium, 30--80% of the added curcumin
disappeared from the mucosal side. No curcumin was however detectable
in the serosal fluid. Less than 3% of the added curcumin was found in the
tissue at the highest concentration. In experiments with [aH]curcumin,
5--6% of added radioactivity was found in the serosal side. TLC examination
of the mucosal extract showed the presence of 2 compounds, 1 corresponding
to curcumin and the other to a less polar, colourless compound. The serosal
fluid had no curcumin but a compound whose RF was identical with the
colourless compound present in the mucosal side. These experiments indicated
that curcumin undergoes transformation during absorption from the
intestine.
 
Date 1981
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/2418/1/Toxicology%2C_Volume_20%2C_Issues_2-3%2C_1981%2C_Pages_251-257.pdf
Vijayalakshmi, R. and Chandrashekara, N. (1981) In vitro studies on the intestinal absorption of curcumin in rats. Toxicology, 20. pp. 251-257.