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Effect of beta- and gamma-isomers of hexachlorocyclohexane on some liver and kidney enzymes in albino rats.

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Title Effect of beta- and gamma-isomers of hexachlorocyclohexane on some liver and kidney enzymes in albino rats.
 
Creator Srinivasan, K.
Radhakrishnamurthy, R.
 
Subject 07 Enzyme Biochemistry
17 Toxicology
 
Description PESTAB. Weanling male rats were maintained for 14-18 days on diets containing no pesticide (controls) or 800 ppm of beta-BHC or gamma-BHC. The animals were observed for 2 weeks and sacrificed during the third week. Protein and the activities of alanine and asparatate 2-oxoglutarate aminotransferase, alkaline and acid phosphatase, glucose-6-phosphatase, and glucose-6-phosphate dehydrogenase in the liver and kidney tissues were determined. During the third week, beta-BHC produced signs of severe toxicity culminating in coma and death; it produced no growth retardation. gamma-BHC produced loss of apetite and growth retardation during the first week only. beta-BHC produced significant increases in hepatic alanine aminotransferase (80%), the renal alkaline and acid phosphatase (125% and 35%, respectively), and hepatic glucose-6-phosphate dehydrogenase (130%), and significant decreases in hepatic aspartate aminotransferase (30%), renal alanine aminotransferase (35%), the hepatic alkaline and acid phosphatases (45% and 40%, respectively), and hepatic glucose-6-phosphatase (30%). gamma-BHC produced significant increase in hepatic alanine aminotransferase (50%), renal acid phosphate dehydrogenase (40%), and significant decreases in hepatic aspartate aminotransferase (30%) and the hepatic alkaline and acid phosphatases (35% each).
 
Date 1977
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/3841/1/Current%20Science%2C%20Volume-46%28%20%281977%29%20598-600.pdf
Srinivasan, K. and Radhakrishnamurthy, R. (1977) Effect of beta- and gamma-isomers of hexachlorocyclohexane on some liver and kidney enzymes in albino rats. Current Science, 46. pp. 598-600.