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Induction of liver mixed function oxygenase system by beta- and gamma-hexachlorocyclohexane.

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Title Induction of liver mixed function oxygenase system by beta- and gamma-hexachlorocyclohexane.
 
Creator Srinivasan, K.
Radhakrishnamurthy, R.
 
Subject 07 Enzyme Biochemistry
12 Metabolism
 
Description The y- isomer of hexachlorocydohexane(HCH) was a more powerful inducer ofmilted function oxygenase system (M FOS)
than the beta- isomer, although the increases in liver weights were more in beta-HCH-treated rats. Induction of MFOS by these HCH
isomers was dose-dependent even 50 ppm dietary level (or 2 weeks was effective. MFOS induction was nearly maximum at the
end of 4 days treatment. Increases in cytochromes P450 and bs, produced by these compounds were not associated with
stimulation of heme synthesis. Stimulation of cytochromes, O-hydroxylase, and N-demethylase by HCH isomers and
phenobarbital was not additive when administered togetber. /1- or)'- HCH and phenobarbital produced an additive effect on
the induction ofNADPH-eytochrome reductase. Exogenous administration of hematin counteracted the induction ofMFOS
by HeH isomers, as in the case of phenobarbital.
 
Date 1983
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/4388/1/Indian%20Journal%20of%20Biochemistry%20and%20Biophysics%2C%20Volume-20%28%20%281983%29%2084-91.pdf
Srinivasan, K. and Radhakrishnamurthy, R. (1983) Induction of liver mixed function oxygenase system by beta- and gamma-hexachlorocyclohexane. Indian Journal of Biochemistry and Biophysics, 20. pp. 84-91.