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14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity

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Relation http://ir.cftri.com/4436/
 
Title 14-Aminotetradecanoic acid exhibits antioxidant activity
and ameliorates xenobiotics-induced cytotoxicity
 
Creator Anup, Srivastava
Jagan Mohan Rao, L.
Shivanandappa, T.
 
Subject 10 Plants
32 Antioxidants
 
Description Natural compounds with free-radical scavenging
activity have potential role in maintaining human health and
preventing diseases. In this study, we report the antioxidant
and cytoprotective properties of 14-aminotetradecanoic acid
(ATDA) isolated from the Decalepis hamiltonii roots.
ATDA is a potent scavenger of superoxide (O2
•-), hydroxyl
(•OH), nitric oxide (•NO), and lipid peroxide (LOO•) physiologically
relevant free radicals with IC50 values in nM
(36–323) range. ATDA also exhibits concentration-dependent
secondary antioxidant activities like reducing power,
metal-chelating activity, and inhibition of protein carbonylation.
Further, ATDA at nM concentration prevented
CuSO4-induced human LDL oxidation. ATDA demonstrated
cytoprotective activity in primary hepatocytes and
Ehrlich ascites tumor cells against oxidative stress inducing
xenobiotics apart from the in vitro free-radical scavenging
activity. The mechanism of cytoprotective action involved
maintaining the intracellular glutathione, scavenging of
reactive oxygen species, and inhibition of lipid peroxidation.
It is suggested that ATDA is a novel bioactive molecule with
potential health implications.
 
Date 2012
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/4436/1/Molecular%20and%20Cellular%20Biochemistry%2C%202012%2C%20Volume%20364%2C%20Numbers%201-2%2C%20Pages%201-9.pdf
Anup, Srivastava and Jagan Mohan Rao, L. and Shivanandappa, T. (2012) 14-Aminotetradecanoic acid exhibits antioxidant activity and ameliorates xenobiotics-induced cytotoxicity. Molecular and Cellular Biochemistry, 364 (1-2). pp. 1-9. ISSN 0300-8177