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Transcriptional Regulation By Nuclear Receptor Homodimers Binding To The Direct Repeat Motif DR1 : Investigations In An in vitro Transcription System Derived From Rat Liver Nuclear Extracts

Electronic Theses of Indian Institute of Science

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Title Transcriptional Regulation By Nuclear Receptor Homodimers Binding To The Direct Repeat Motif DR1 : Investigations In An in vitro Transcription System Derived From Rat Liver Nuclear Extracts
 
Creator Harish, S
 
Subject Biochemistry
Nuclear Receptors (NRs)
Retinoid X Receptor (RXR)
Electro Mobility Shift Assays (EMSA)
Chromatin Assembly
Plasmids Constructs
Chicken Ovalbumin Upstream Promoter Transcription Factor I (COUP-TFI)
 
Description Nuclear receptors (NRs) are important transcription factors involved in the regulation of a variety of physiological processes such as embryonic development, cell differentiation and homeostasis (for review, see Mangelsdorf et al., 1995 TenBaum and Baniahrned, 1997). In contrast to membrane bound receptors, they bind small lipophilic ligands and function in the nucleus as ligand-modulated transcription factors. The ligands for nuclear receptors include steroids (glucocorticoids, progestins, mineralocorticoids, androgens and estrogens), vitamin D3, retinoids, thyroid hormone, prostaglandins, farnesoids etc. Several other nuclear receptors are classified as orphan receptors for which no ligand has yet been identified.

More than 300 nuclear receptors have now been identified and together these proteins comprise the single largest family of metazoan transcription factors, the nuclear receptor superfamily. Recently, a unified nomenclature has been evolved (nuclear receptor nomenclature committee, 1999), a summary of which is presented in Table 1.
 
Publisher Indian Institute of Science
 
Contributor Rangarajan, P N
 
Date 2005-11-23T10:31:06Z
2005-11-23T10:31:06Z
2005-11-23T10:31:06Z
2000-02
 
Type Electronic Thesis and Dissertation
 
Format 16741437 bytes
application/pdf
 
Identifier http://hdl.handle.net/2005/164
null
 
Language en
 
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