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Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products : (+)-1S-Minwanenone, (+)-SCH 642305 And 6-EPI-(-)-Hamigeran B

Electronic Theses of Indian Institute of Science

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Title Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products : (+)-1S-Minwanenone, (+)-SCH 642305 And 6-EPI-(-)-Hamigeran B
 
Creator Murlidhar, Shinde Harish
 
Subject Minwanenone - Synthesis
Natural Products - Synthesis
Hamigeran - Synthesis
Bioactive Compounds
Bioactive Natural Products
Seco-Prezizaanes
(+)-SCH 642305
6-EPI-(-)-Hamigeran B
(+)-1S-Minwanenone
Organic Chemistry
 
Description Natural product synthesis is one of the most creative branch of chemistry in terms of its boundless scope for innovation and has stimulated several generations of synthetic organic chemists. With advancement in the technology, particularly in the isolation and purification techniques, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, even to those complex molecules, which are available only in microscopic quantities from natural sources. Concurrently, one has witnessed tremendous advances in the availability of new synthetic methodologies with high region-, stereo-, and enantiocontrol for one or multiple C-C bond formations and rapid generation of molecular complexity. These developments have rekindled interest with total synthesis of natural products as platforms for testing and validating new reactions and strategies. Many natural products exhibit wide range of biological activities and thus provide good leads in drug discovery but quite often such bioactive compounds are obtained only in minute quantities from Nature. Hence, there is need to synthesize them to obtain requisite quantities and build diversity around their scaffold to further explore their therapeutic potential. Thus, natural product synthesis combines both intellectual challenge and possible application for human wellbeing. Our research group is actively engaged in the synthesis of structurally complex, bioactive natural products and as a part of this endeavour, total syntheses of several bioactive compounds have been accomplished in our laboratory in recent past.
The present thesis has also evolved around the ongoing theme directed towards natural product synthesis and is organized under three chapters. Chapter I: Total synthesis of (+)-1S-Minwanenone Chapter II: Enantioselective total synthesis of the bioactive natural product (+)-Sch 642305. Chapter III: Enantiospecific total synthesis of 6-epi-(-)-Hamigeran B.
 
Contributor Mehta, Goverdhan
 
Date 2009-08-13T06:21:39Z
2009-08-13T06:21:39Z
2009-08-13T06:21:39Z
2007-07
 
Type Thesis
 
Identifier http://hdl.handle.net/2005/590
 
Language en_US
 
Relation G21045