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Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice.

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Relation http://ir.cftri.com/11471/
http://10.1007/s00394-013-0507-9
 
Title Olive oil improves the intestinal absorption and bioavailability
of lutein in lutein-deficient mice.
 
Creator Nidhi, Bhatiwada
Mamatha, B. S.
Baskaran, V.
 
Subject 01 Oilseeds
 
Description To investigate the influence of olive (OO),
groundnut (GNO), soybean (SBO), sunflower (SFO), rice
bran (RBO), corn (CO), palm (PO) oil or mixed micelle
(control) on absorption kinetics and bioavailability of
lutein in lutein-deficient mice. Additional aim was to correlate
the activity of intestinal triacylglycerol lipase with
intestinal and plasma lutein levels.
Methods After induction of lutein deficiency, mice
(n = 165) were divided into eight groups (OO, SFO, GNO,
RBO, PO, CO, SBO and control; n = 20/group) and the
remaining (n = 5) were used as baseline (0 h). Groups
were further divided into four subgroups (n = 5/subgroup)
and were intubated with lutein (200 lM) dispersed in different
vegetable oils. Plasma and tissue (intestine, liver and
eyes), lutein, triglycerides, intestinal triacylglycerol lipases
and fatty acid profile of plasma and tissues were measured
at different time intervals.
Results The percentage area under the curve value for
plasma lutein in OO and GNO was higher by 41.8 and
5.1 %, while it was lower in other groups (18.2–53.3 %),
when compared to control. Similarly, the percentage area
under the curve for eye lutein in OO and GNO groups was
higher by 35.2 and 4.8 %, whereas in other groups it was
lower (5.4–69 %) than in control. Results show that olive
oil facilitates the lutein absorption more compared to other
vegetable oils, which may be due to the difference in fatty
acid composition and higher activity of intestinal triacylglycerol
lipase.
Conclusions Dietary olive oil rich in oleic acid improves
the bioavailability and accumulation of lutein in luteindeficient
mice by modifying the intestinal triacylglycerol
lipase activity.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11471/1/Eur%20Jl%20of%20Nutr%202014_53_1_117.pdf
Nidhi, Bhatiwada and Mamatha, B. S. and Baskaran, V. (2014) Olive oil improves the intestinal absorption and bioavailability of lutein in lutein-deficient mice. European Journal of Nutrition, 53. pp. 117-126.