Record Details

In Vitro and In Vivo Studies for Hypolipidemic and Hypocholesterolemic Activities in Prepared Novel Probiotic Functional Food.

IR@CSIR-CFTRI

View Archive Info
 
 
Field Value
 
Relation http://ir.cftri.com/11536/
 
Title In Vitro and In Vivo Studies for Hypolipidemic and
Hypocholesterolemic Activities in Prepared Novel Probiotic
Functional Food.
 
Creator Sohini, Jana
 
Subject 04 Fungi
04 Functional foods
 
Description Due to increasing prevalence of various chronic diseases i.e. obesity, diabetes,
cardiovascular diseases and cancer that are associated with poor food habits, there is an
increasing demand for development of functional food with new probiotic microbes that
can enhance biofunctionality of foods against these health ailments. In the present work
an innovative probiotic product with cereals and legumes has been developed using
Lactobacillus sp. with low cholesterol and triglyceride content. The product showed to
have good antioxidant activity, antimicrobial activity against E. coli, volatile compounds
of therapeutic importance and beneficial fatty acid profile. In vivo study with male Wistar
rats was done where the animals were fed with the product having different CFU levels
of 1x109/ml, 2x109/ml and 4x109/ml of the product. The in vivo study showed the product
had significant antiobesity, hypocholesterolemic and hypolipidemic property. Besides,
studies done on antioxidant activity, liver function test and glucose level also reveals that
the strain Lactobacillus sp. can considerably increase the antioxidant activity and control
the normal liver function properly. Hence, the probiotic product can reinforce the
antioxidant defense mechanism, proper liver function and reduce cholesterol and
triglyceride level in the body. This high value probiotic food, when consumed, may
improve human health.
 
Contributor Renu, Agrawal
 
Date 2013
 
Type Student Project Report
NonPeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/11536/1/Sohini.pdf
Sohini, Jana (2013) In Vitro and In Vivo Studies for Hypolipidemic and Hypocholesterolemic Activities in Prepared Novel Probiotic Functional Food. [Student Project Report] (Submitted)