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Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds.

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Relation http://ir.cftri.com/11577/
http://doi.org/10.1007/s13197-011-0488-8
 
Title Structure-function activity of dehydrozingerone
and its derivatives as antioxidant
and antimicrobial compounds.
 
Creator Ismail, R. Kubra
Bettadaiah, B. K.
Pushpa, S. Murthy
Jagan Mohan Rao, L.
 
Subject 30 Spices/Condiments
32 Antioxidants
 
Description Dehydrozingerone, structural half analogue of
curcumin, is a phenolic compound isolated from ginger
(Zingiber officinale) rhizomes. Dehydrozingerone and
several of its derivatives such as glucopyranosides and its
tetra acetate derivative and 4-O-acetyl and methyl derivatives
of dehydrozingerone were synthesized in the present
study. Dehydrozingerone, synthesised with improved yield
was used for the synthesis of Dehydrozingerone 4-O-β-Dglucopyranoside
(first time report) by modified Koenigs-
Knorr-Zemplén method. Structures of all the compounds
have been established using spectroscopic methods. These
compounds were tested for radical scavenging activity by
DPPH and FRAP method as well as for antibacterial and
antifungal activities. The parent molecule exhibited better
scavenging activity as compared to its derivatives indicating
the significance of free phenolic hydroxyl group. Also,
Dehydrozingerone and its derivatives exhibited antibacterial
as well as antifungal activity due to the conjugation system
present, which includes α,β-unsaturated carbonyl (C = O)
group. This study gave an insight into structural requirements
for dehydrozingerone activity.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11577/1/Jl%20of%20Food%20Sci%20%26%20Tech_2014_51_2_245.pdf
Ismail, R. Kubra and Bettadaiah, B. K. and Pushpa, S. Murthy and Jagan Mohan Rao, L. (2014) Structure-function activity of dehydrozingerone and its derivatives as antioxidant and antimicrobial compounds. Journal of Food Science and Technology, 51 (2). pp. 245-255.