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Protective Effects of Geraniol (a Monoterpene) in a Diabetic Neuropathy Rat Model: Attenuation of Behavioral Impairments and Biochemical Perturbations.

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Title Protective Effects of Geraniol
(a Monoterpene) in a Diabetic Neuropathy
Rat Model: Attenuation of Behavioral
Impairments and Biochemical
Perturbations.
 
Creator Sathya, N. Prasad
Dr., Muralidhara
 
Subject 04 Diabetes Mellitus
 
Description Involvement of oxidative stress, inflammatory response,
and mitochondrial dysfunction in the development of diabetic
neuropathy (DN) is well appreciated. The present
study examines the potential of geraniol (GE), a wellknown
phytoconstituent commonly found in lemon,
spices, rose oil, etc., to attenuate DN-associated oxidative/
nitrosative stress by employing a streptozotocin
(STZ) diabetic rat model. STZ-induced diabetic rats provided
with oral supplements of GE (100 mg/kg bw/day, 8
weeks) exhibited significant improvement in tail-flick
latency (sensory function) and the narrow beam test
(motor function). Terminally, elevated levels of oxidative
markers (reactive oxygen species, malondialdehyde,
hydroperoxides) in cytosol of the sciatic nerve (SN) and in
selected regions of the brain of diabetic rats were markedly
reduced by GE supplements. Furthermore, GE significantly
diminished the levels of protein carbonyls (a
measure of protein oxidation) and nitrites in diabetic rats.
In addition, in mitochondria, GE supplements restored the
activities of enzymes, such as complexes I–III, succinate
dehydrogenase, and citrate synthase, in brain regions of
diabetic rats, with a concomitant reduction in the levels of
oxidative markers. GE significantly lowered the enhanced
cytosolic calcium levels and acetylcholinesterase activity
in the SN and the brain regions of diabetic rats. Depleted
dopamine levels evident in the SN and the cortex/striatum
among diabetic rats were restored by GE. From our data,
we hypothesize that GE may be a promising therapeutic
candidate in the management of DN in humans. Further
understanding of the molecular mechanisms of its neuromodulatory
effects is essential in order to exploit its therapeutic
efficacy.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11622/1/Journal%20of%20Neuroscience%20Research%2092%201205%E2%80%931216%20%282014%29.pdf
Sathya, N. Prasad and Dr., Muralidhara (2014) Protective Effects of Geraniol (a Monoterpene) in a Diabetic Neuropathy Rat Model: Attenuation of Behavioral Impairments and Biochemical Perturbations. Journal of Neuroscience Research :, 92. pp. 1205-1216.