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Dietary fatty acid determines the intestinal absorption of lutein in lutein deficient mice.

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Relation http://ir.cftri.com/11656/
http://dx.doi.org/10.1016/j.foodres.2014.06.034
 
Title Dietary fatty acid determines the intestinal absorption of lutein in lutein
deficient mice.
 
Creator Nidhi, Bhatiwada
Ramaprasad, T. R.
Baskaran, V.
 
Subject 17 Fatty Acid Chemistry
 
Description The present investigation was undertaken to study the influence of dietary lipids [olive (OO), coconut (CNO),
groundnut (GNO), soybean (SBO), sunflower (SFO), rice bran (RBO), corn (CO), palm (PO), fish (FO) oils] on
the bioavailability and antioxidant property of lutein in lutein deficient (LD)mice. Lutein (200 μM) was dispersed
in dietary lipids and administered to LD mice for a period of 15 days. The plasma lutein levels were found to be
highest in OO (82%) and CNO (68%), when compared to the control (mixed micelle) group. Further, positive correlation
was found between intestinal triacylglycerol lipase and plasma lutein levels, confirming the crucial role
of intestinal lipase on lutein micellarization and its intestinal uptake. Results revealed an affirmative correlation
between triglycerides, lowdensity lipoproteins and high density lipoprotein levelswith plasma and tissue lutein
levels, signifying their role in the transportation of newly absorbed lutein to target tissues. Furthermore, lutein
accumulation in the liver and the eye was highest in the OO (120% and 117%) and CNO (105% and 109%) fed
groups, compared to control. Lutein deficiency resulted in elevated (p b 0.05) levels of lipid peroxides, superoxide
dismutase, and catalase in plasma and liver microsomes, which have been decreased significantly on feeding
lutein. These resultsmay be due to the influence of oleic (dominant in OO) and lauric (dominant in CNO) acids on
the activity of intestinal lipase, portal absorption, triglycerides, lipoprotein or cholesterol flux between liver and
peripheral tissues, which may modulate the uptake and transport of lutein.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11656/1/Food%20Research%20International%2C%20Volume%2064%2C%20October%202014%2C%20Pages%20256-263.pdf
Nidhi, Bhatiwada and Ramaprasad, T. R. and Baskaran, V. (2014) Dietary fatty acid determines the intestinal absorption of lutein in lutein deficient mice. Food Research International, 64. pp. 256-263.