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Enzyme Catalyzed Synthesis of Serotonyl and Epinephryl Glycosides Using Amyloglucosidase from Rhizopus Mold.

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http://www.cibtech.org/jls.htm
 
Title Enzyme Catalyzed Synthesis of Serotonyl and Epinephryl Glycosides Using Amyloglucosidase from Rhizopus Mold.
 
Creator Ganesan, V.
Divakar, S.
 
Subject 16 Enzyme Chemistry
 
Description Glycosylation of phenolic hydroxyl groups of serotonin and epinephrine, using an amyloglucosidase from Rhizopus mold was carried out with D-glucose, D-galactose, D-mannose and D-ribose in di-isopropyl ether solvent to yield 13-29% of glycosides in 48h. NMR spectroscopic data indicated that the reaction occurred between the phenolic -OH group of serotonin and C1α /β and / or 6-O-groups of D-glucose, D-galactose, D-mannose and D-ribose. In case of epinephrine, 4 –OH and 3 –OH groups reacted with C1 β anomer of D-glucose and C-1 α/β anomers of D-mannose.
 
Date 2011
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11706/1/Ind%20Jl%20of%20Fundamental%20and%20Applied%20Life%20Sci_2011_1%282%29.pdf
Ganesan, V. and Divakar, S. (2011) Enzyme Catalyzed Synthesis of Serotonyl and Epinephryl Glycosides Using Amyloglucosidase from Rhizopus Mold. Indian Journal of Fundamental and Applied Life Sciences, 1 (2). pp. 15-21. ISSN 2231-6345