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Biodegradable chitosan-glycolipid hybrid nanogels: A novel approach to encapsulate fucoxanthin for improved stability and bioavailability.

IR@CSIR-CFTRI

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Relation http://ir.cftri.com/11722/
http://dx.doi.org/10.1016/j.foodhyd.2014.08.004
 
Title Biodegradable chitosan-glycolipid hybrid nanogels: A novel approach
to encapsulate fucoxanthin for improved stability and bioavailability.
 
Creator Ravi, Hindupur.
Baskaran, V.
 
Subject 16 Nutritive value
04 Vitamins
 
Description This study aimed to improve the stability and biological availability of carotenoid fucoxanthin (FUCO)
encapsulated in chitosan (CS) e sodium tripolyphosphate (TPP) e glycolipid (GL) nanogels, prepared by
ionic gelation method. Scanning Electron Microscopic analysis and Dynamic Light Scattering examination
revealed smooth and spherical nanogels with size range of 200e550 nm in weight ratios of CS: TPP
(2.5:1), CS: GL (1:0.5). The zeta potential values (þ30 to þ50 mV) indicate that CS-NGs with FUCO þ GL
were more stable than that of CS-NGs þ FUCO with no GL (þ15 mV). The Fourier Transform Infrared
Spectroscopy (FTIR) showed an extensive hydrogen bonding interaction between the FUCO and CS. X-ray
Diffraction revealed FUCO is distributed in a disordered (amorphous) state in CS-NGs. Encapsulation
efficiency, loading capacity and the yield of CS-NGs with FUCO þ GL were 90%, 47% and 70%, respectively
which is, significantly higher, than that of CS-NGs þ FUCO without GL. Stability studies illustrated that
glycolipid offers enhanced FUCO stability (t1/2, 45 h) with CS-NGs compared to that of with no GL (t1/2,
15 h) and standard FUCO (t1/2,
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
Rights —
 
Identifier http://ir.cftri.com/11722/1/Food%20Hydrocolloids%2C%20Volume%2043%2C%20January%202015%2C%20Pages%20717-725.pdf
Ravi, Hindupur. and Baskaran, V. (2015) Biodegradable chitosan-glycolipid hybrid nanogels: A novel approach to encapsulate fucoxanthin for improved stability and bioavailability. Food Hydrocolloids, 43. pp. 717-725.