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Beneficial hypolipidemic influence of a combination of dietary fenugreek (Trigonella foenum‑graecum) seeds and garlic (Allium sativum) in induced hypercholesterolemic rats.

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Relation http://ir.cftri.com/11787/
http://dx.doi.org/10.1007/s00217-014-2408-4
 
Title Beneficial hypolipidemic influence of a combination of dietary
fenugreek (Trigonella foenum‑graecum) seeds and garlic (Allium
sativum) in induced hypercholesterolemic rats.
 
Creator Mukthamba, P.
Srinivasan, K.
 
Subject 30 Spices/Condiments
32 Antioxidants
 
Description Health beneficial hypocholesterolemic and
antioxidant influences of dietary fenugreek seeds (Trigonella
foenum-graecum), garlic (Allium sativum), and their
combination included along with a high cholesterol diet
(HCD) were evaluated in Wistar rats. Dietary interventions
were made by inclusion of 10 % fenugreek seed powder
or 2 % garlic powder or their combination in HCD/normal
diet groups. These dietary interventions significantly
(p < 0.05) countered the hypercholesterolemia; the effect
produced being more by the combination. LDL-associated
cholesterol was particularly countered by 35, 15, and 50 %
with fenugreek, garlic, and fenugreek + garlic, respectively,
while HDL-associated cholesterol was restored.
Elevated cholesterol:phospholipid ratio and atherogenicity
index were also reversed by these dietary interventions,
the effect being higher in the case of fenugreek + garlic.
Hepatic cholesterol was lowered by dietary fenugreek,
garlic, or their combination (p < 0.05). While the elevated
myocardial cholesterol was countered by 28, 15, and 52 %
with the respective interventions in HCD-fed situation,
and cholesterol:phospholipid ratio was also beneficially
modulated (p < 0.05) with higher benefit from the combination.
Increase in lipid peroxides in liver and heart was
effectively countered by dietary fenugreek, garlic, and
fenugreek + garlic, with a restoration of vitamin E. The
reduction in lipid peroxides was 34 and 57 % by fenugreek
+ garlic in these tissues, respectively. The diminished
activity of glutathione peroxidase in serum, liver and heart,
and of catalase in serum was effectively restored (p < 0.05)
by these dietary interventions. This study indicated that dietary fenugreek and garlic may have higher cardio protective
influence when consumed together, and this may
be strategic to derive maximum nutraceutical benefit from
these ingredients.
 
Date 2015
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11787/1/European%20Food%20Research%20and%20Technology%20May%202015%2C%20Volume%20240%2C%20Issue%205%2C%20pp%201049-1058.pdf
Mukthamba, P. and Srinivasan, K. (2015) Beneficial hypolipidemic influence of a combination of dietary fenugreek (Trigonella foenum‑graecum) seeds and garlic (Allium sativum) in induced hypercholesterolemic rats. European Food Research and Technology, 240 (5). pp. 1049-1058.