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Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats.

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Relation http://ir.cftri.com/11828/
http://dx.doi.org/10.1007/s00210-014-1001-5
 
Title Fungal metabolite nigerloxin ameliorates diabetic nephropathy
and gentamicin-induced renal oxidative stress in experimental
rats.
 
Creator Suresha, B. S.
Srinivasan, K.
 
Subject 04 Diabetes Mellitus
 
Description Elevated polyol pathway enzyme activities and
oxidative stress play an important role in the development
and progression of diabetic nephropathy. Here, we investigated
the beneficial influence of nigerloxin, a fungal metabolite
and a potent aldose reductase inhibitor and free radical scavenger
in the kidney of streptozotocin-induced diabetic rats. A
group of diabetic rats was orally administered with nigerloxin
for 30 days (100 mg/kg). Diabetic rats showed increased lipid
peroxides, advanced glycation end products (AGEs), elevated
activities of polyol pathway enzymes, and lowered antioxidant
defense system in kidney. Administration of nigerloxin
decreased kidney lipid peroxides and AGEs. Activities of
polyol pathway enzymes were reduced while activities of all
antioxidant enzymes, glutathione, and ascorbic acid were
elevated in the kidney of nigerloxin-treated diabetic rats. We
also investigated antioxidant potential of nigerloxin in
gentamicin-induced nephrotoxicity in Wistar rats. Groups of
rats were orally administered with nigerloxin for 8 days
(25 mg or 100 mg kg−1 body weight day−1) along with
gentamicin (80 mg/kg, i.p., for 8 days). Gentamicin induced
increase in lipid peroxides, decrease in glutathione and activities
of antioxidant enzymes in the kidney, and increase in
blood creatinine, and urea concentrations were significantly
countered by nigerloxin treatment. Thus, the results indicated
the beneficial influence of nigerloxin on polyol pathway and
oxidative stress associated with diabetes, which are implicated
in ameliorating the development of diabetic nephropathy.
Nigerloxin also ameliorated oxidative stress induced by gentamicin
in the renal tissue.
 
Date 2014
 
Type Article
PeerReviewed
 
Format application/pdf
 
Language en
 
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Identifier http://ir.cftri.com/11828/1/Naunyn_Schemeid_Arch_Pharm_2014_387_849.pdf
Suresha, B. S. and Srinivasan, K. (2014) Fungal metabolite nigerloxin ameliorates diabetic nephropathy and gentamicin-induced renal oxidative stress in experimental rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 387. pp. 849-859.